Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues
and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome …

Colorectal cancer (CRC) at advanced stages is rarely curable, underscoring the importance
of exploring the mechanism of CRC progression and invasion. NOD-like receptor family …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition
contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation …

Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …

Nucleotide-binding leucine-rich repeat-containing proteins, or NOD-like receptors (NLRs),
are intracellular innate immune sensors that can regulate several signaling pathways …