Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

BACKGROUND The social environment shapes human health, producing strong
relationships between social factors, disease risk, and survival. The strength of these links …

Emerging research demonstrates that microbiota-gut–brain (MGB) axis changes are
associated with depression onset, but the mechanisms underlying this observation remain …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

While it is well known from numerous epidemiologic investigations that social determinants
(socioeconomic, environmental, and psychosocial factors exposed to over the life-course) …

Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …

Are differences in hypothalamic-pituitary-adrenal (HPA) axis activation across the adult life
span linked to differences in survival? This question has been the subject of considerable …

The exciting field of human social genomics provides an evolutionarily informed, multilevel
framework for understanding how positive and negative social–environmental experiences …

Research in the basic biology of ageing is increasingly identifying mechanisms and
modifiers of ageing in short-lived organisms such as worms and mice. The ultimate goal of …

Exposure to acute versus chronic stressors and threats activates the immune system in
adaptive and maladaptive manners respectively. Chronic activation arising from persistent …