B7-H3: an attractive target for antibody-based immunotherapy
The recent impressive clinical responses to antibody-based immunotherapy have prompted
the identification of clinically relevant tumor antigens that can serve as targets in solid …
the identification of clinically relevant tumor antigens that can serve as targets in solid …
Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy
B Zhao, H Li, Y ** treatment that modifies the immune
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Identifying the mechanisms underlying the regulation of immune checkpoint molecules and
the therapeutic impact of targeting them in cancer is critical. Here we show that high …
the therapeutic impact of targeting them in cancer is critical. Here we show that high …
Molecular pathways: targeting B7-H3 (CD276) for human cancer immunotherapy
E Picarda, KC Ohaegbulam, X Zang - Clinical Cancer Research, 2016 - AACR
Abstract B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28
families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition …
families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition …
[HTML][HTML] B7-H3, a checkpoint molecule, as a target for cancer immunotherapy
S Yang, W Wei, Q Zhao - International journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may
be a promising target for cancer treatment. B7-H3 protein was demonstrated to be …
be a promising target for cancer treatment. B7-H3 protein was demonstrated to be …
Clinical insights into novel immune checkpoint inhibitors
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological …
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
The role of CD276 in cancers
S Liu, J Liang, Z Liu, C Zhang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Objective Aberrant expression of the immune checkpoint molecule, CD276, also known as
B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe …
B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe …
B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression
R Wang, Y Ma, S Zhan, G Zhang, L Cao, X Zhang… - Cell death & …, 2020 - nature.com
Tumor angiogenesis is a hallmark of cancer and is involved in the tumorigenesis of solid
tumors. B7-H3, an immune checkpoint molecule, plays critical roles in proliferation …
tumors. B7-H3, an immune checkpoint molecule, plays critical roles in proliferation …
[HTML][HTML] B7-H3 role in the immune landscape of cancer
The field of immunotherapy is a continually expanding niche in cancer biology research. In
the last two decades, there has been significant progress in identifying better targets and …
the last two decades, there has been significant progress in identifying better targets and …