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Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy
B Zhao, H Li, Y ** treatment that modifies the immune
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …
system and enhances the antitumor immune response. B7-H3 (CD276), a member of the B7 …
B7-H3: an attractive target for antibody-based immunotherapy
F Kontos, T Michelakos, T Kurokawa… - Clinical Cancer …, 2021 - aacrjournals.org
The recent impressive clinical responses to antibody-based immunotherapy have prompted
the identification of clinically relevant tumor antigens that can serve as targets in solid …
the identification of clinically relevant tumor antigens that can serve as targets in solid …
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Identifying the mechanisms underlying the regulation of immune checkpoint molecules and
the therapeutic impact of targeting them in cancer is critical. Here we show that high …
the therapeutic impact of targeting them in cancer is critical. Here we show that high …
B7-H3, a checkpoint molecule, as a target for cancer immunotherapy
S Yang, W Wei, Q Zhao - International journal of biological …, 2020 - pmc.ncbi.nlm.nih.gov
B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a
promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in …
promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in …
Molecular pathways: targeting B7-H3 (CD276) for human cancer immunotherapy
E Picarda, KC Ohaegbulam, X Zang - Clinical Cancer Research, 2016 - aacrjournals.org
Abstract B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28
families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition …
families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition …
Clinical insights into novel immune checkpoint inhibitors
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
The role of CD276 in cancers
S Liu, J Liang, Z Liu, C Zhang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Objective Aberrant expression of the immune checkpoint molecule, CD276, also known as
B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe …
B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe …
B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression
R Wang, Y Ma, S Zhan, G Zhang, L Cao, X Zhang… - Cell death & …, 2020 - nature.com
Tumor angiogenesis is a hallmark of cancer and is involved in the tumorigenesis of solid
tumors. B7-H3, an immune checkpoint molecule, plays critical roles in proliferation …
tumors. B7-H3, an immune checkpoint molecule, plays critical roles in proliferation …
B7-H3 role in the immune landscape of cancer
The field of immunotherapy is a continually expanding niche in cancer biology research. In
the last two decades, there has been significant progress in identifying better targets and …
the last two decades, there has been significant progress in identifying better targets and …
JAK/STAT signaling in hepatocellular carcinoma
JJ Hin Tang, DK Hao Thng, JJ Lim, TB Toh - Hepatic oncology, 2020 - Taylor & Francis
Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …