Evolution and emergence of Mycobacterium tuberculosis

M Orgeur, C Sous, J Madacki… - FEMS microbiology …, 2024 - academic.oup.com
Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

A new evolutionary scenario for the Mycobacterium tuberculosis complex

R Brosch, SV Gordon, M Marmiesse, P Brodin… - Proceedings of the …, 2002 - pnas.org
The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …

Laboratory diagnosis of tuberculosis in resource-poor countries: challenges and opportunities

LM Parsons, Á Somoskövi, C Gutierrez… - Clinical microbiology …, 2011 - journals.asm.org
With an estimated 9.4 million new cases globally, tuberculosis (TB) continues to be a major
public health concern. Eighty percent of all cases worldwide occur in 22 high-burden, mainly …

Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis

MC Gutierrez, S Brisse, R Brosch, M Fabre… - PLoS …, 2005 - journals.plos.org
The highly successful human pathogen Mycobacterium tuberculosis has an extremely low
level of genetic variation, which suggests that the entire population resulted from clonal …

Bovine tuberculosis: an old disease but a new threat to Africa

WY Ayele, SD Neill, J Zinsstag… - … of Tuberculosis and …, 2004 - ingentaconnect.com
Bovine tuberculosis (TB) is a disease characterised by progressive development of specific
granulomatous le-sions or tubercles in lung tissue, lymph nodes or other organs …

Genomic insights into tuberculosis

JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

P Supply, M Marceau, S Mangenot, D Roche… - Nature …, 2013 - nature.com
Global spread and limited genetic variation are hallmarks of M. tuberculosis, the agent of
human tuberculosis. In contrast, Mycobacterium canettii and related tubercle bacilli that also …

Impact of genotypic studies on mycobacterial taxonomy: the new mycobacteria of the 1990s

E Tortoli - Clinical microbiology reviews, 2003 - journals.asm.org
The advancement of genetic techniques has greatly boosted taxonomic studies in recent
years. Within the genus Mycobacterium, 42 new species have been detected since 1990 …