Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …

As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

There is persuasive clinical and experimental evidence that macrophages promote cancer
initiation and malignant progression. During tumor initiation, they create an inflammatory …