Based on several convergent lines of investigation, we make two hypotheses which are
sufficient to explain many phenomena of growth regulation in both normal and cancer cells …

The nicotine receptor for the neurotransmitter acetylcholine is an allosteric protein
composed of four different subunits assembled in a transmembrane pentamer α2 βγδ. The …

The membrane of tissue‐cultured chick pectoral muscle contains an ionic channel which is
activated by membrane stretch. Nicotinic channels and Ca2+‐activated K+ channels are not …

The nicotinic acetylcholine receptor is a cation-selective, ligand-gated ion channel, involved
in signal transmission at the chemical synapse. This paper reports the three-dimensional …

Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …

The glycine receptor of rat spinal cord is an oligomeric membrane glycoprotein of molecular
mass 250,000 daltons that contains three polypeptides of 48,000, 58,000, and 93,000 …

We have stably expressed in fibroblasts different pairs of a and non-a subunits of the mouse
muscle nicotinic acetylcholine receptor (AChR). They and 6, but not the B, subunits …

Like other proteins, ion channels are charged. The amino acid sequence contains acidic
and basic amino acids that are positively or negatively charged at physiologic pH. Other …

Identification of all residues involved in the recognition and binding of cholinergic ligands
(eg agonists, competitive antagonists, and noncompetitive agonists) is a primary objective to …

Out of about 2,340 species of snakes living on the earth, more than 420 species are
venomous (Dowling and Duellman, 1978). The venoms of proteroglyphous or fixed …