Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential
MS Mercier, D Lodge - Neurochemical research, 2014 - Springer
Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS),
exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) …
exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) …
Therapeutic potential of group III metabotropic glutamate receptors
H Lavreysen, FM Dautzenberg - Current medicinal chemistry, 2008 - ingentaconnect.com
Metabotropic glutamate (mGlu) receptors have received much attention, driven by a strong
belief in the potential of these modulatory glutamate receptors as drug targets. So far, major …
belief in the potential of these modulatory glutamate receptors as drug targets. So far, major …
Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor …
P Bäckström, P Hyytiä - European journal of pharmacology, 2005 - Elsevier
Glutamatergic neurotransmission has been suggested to modulate cue-induced drug-
seeking behavior. Here we examined the effects of metabotropic glutamate receptor …
seeking behavior. Here we examined the effects of metabotropic glutamate receptor …
Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands
CL Frisby, JP Mattsson, JM Jensen, A Lehmann, J Dent… - Gastroenterology, 2005 - Elsevier
Background & Aims: Transient lower esophageal sphincter relaxation (TLESR) is the major
mechanism of gastroesophageal acid reflux. TLESR is mediated via vagal pathways, which …
mechanism of gastroesophageal acid reflux. TLESR is mediated via vagal pathways, which …
Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event‐related oscillations and alcohol dependence
ACH Chen, Y Tang, M Rangaswamy… - American Journal of …, 2009 - Wiley Online Library
Evidence suggests the P3 amplitude of the event‐related potential and its underlying
superimposed event‐related oscillations (EROs), primarily in the theta (4–5 Hz) and delta (1 …
superimposed event‐related oscillations (EROs), primarily in the theta (4–5 Hz) and delta (1 …
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata
BACKGROUND AND PURPOSE Increased firing of the glutamatergic pathway between the
subthalamic nucleus and substantia nigra pars reticulata (SNpr) contributes to the abnormal …
subthalamic nucleus and substantia nigra pars reticulata (SNpr) contributes to the abnormal …
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease
Background and purpose: Increased glutamatergic innervation of the substantia nigra pars
reticulata (SNpr) and pars compacta (SNpc) may contribute to the motor deficits and …
reticulata (SNpr) and pars compacta (SNpc) may contribute to the motor deficits and …
Systemic administration of the potent mGlu8 receptor agonist (S)-3, 4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor …
AM Linden, M Bergeron, M Baez, DD Schoepp - Neuropharmacology, 2003 - Elsevier
The effect of a novel and potent metabotropic glutamate 8 (mGlu8) receptor agonist,(S)-3, 4-
dicarboxyphenylglycine (DCPG), was studied in vivo in mouse brain. c-Fos expression was …
dicarboxyphenylglycine (DCPG), was studied in vivo in mouse brain. c-Fos expression was …
Metabotropic glutamate receptors in GtoPdb v. 2023.1
F Acher, G Battaglia, H Bräuner-Osborne… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Metabotropic glutamate (mGlu) receptors (nomenclature as agreed by the NC-IUPHAR
Subcommittee on Metabotropic Glutamate Receptors [351]) are a family of G protein …
Subcommittee on Metabotropic Glutamate Receptors [351]) are a family of G protein …
Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways
RL Young, NJ Cooper, LA Blackshaw - Neuropharmacology, 2008 - Elsevier
Metabotropic glutamate receptors (mGluR) are classified into groups I (excitatory), II and III
(inhibitory) mGluR. Activation of peripheral group III mGluR (mGluR4, mGluR6, mGluR7 …
(inhibitory) mGluR. Activation of peripheral group III mGluR (mGluR4, mGluR6, mGluR7 …