Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

The triazole nucleus is one of the most important and well known heterocycles which is a
common and integral feature of a variety of natural products and medicinal agents. Triazole …

Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

There has been considerable interest in the development of novel heterocyclic compounds
with varied biological activities. Triazoles are a special class of heterocyclic compounds with …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

A new class of β-aryloxyquinolines 3a–i and their pyrano [3, 2-c] chromene derivatives 6a–r
incorporating a validated molecular target has been synthesized via a nucleophilic …

The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

Antimicrobials have allowed medical advancements over several decades. However, the
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …

We have designed and synthesized both the quinoline and naphthalene based molecules
influenced by the unique structural make-up of mefloquine and TMC207, respectively. These …