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Inferring balancing selection from genome-scale data
The identification of genomic regions and genes that have evolved under natural selection is
a fundamental objective in the field of evolutionary genetics. While various approaches have …
a fundamental objective in the field of evolutionary genetics. While various approaches have …
From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …
a small number of genes and thereby molecular mechanisms have been discovered …
CaeNDR, the Caenorhabditis Natural Diversity Resource
Studies of model organisms have provided important insights into how natural genetic
differences shape trait variation. These discoveries are driven by the growing availability of …
differences shape trait variation. These discoveries are driven by the growing availability of …
Ancient diversity in host-parasite interaction genes in a model parasitic nematode
L Stevens, I Martínez-Ugalde, E King, M Wagah… - Nature …, 2023 - nature.com
Host-parasite interactions exert strong selection pressures on the genomes of both host and
parasite. These interactions can lead to negative frequency-dependent selection, a form of …
parasite. These interactions can lead to negative frequency-dependent selection, a form of …
The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages
Nematodes are important parasites of people and animals, and in natural ecosystems they
are a major ecological force. Strongyloides ratti is a common parasitic nematode of wild rats …
are a major ecological force. Strongyloides ratti is a common parasitic nematode of wild rats …
Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes
Caenorhabditis nematodes form an excellent model for studying how the mode of
reproduction affects genetic diversity, as some species reproduce via outcrossing whereas …
reproduction affects genetic diversity, as some species reproduce via outcrossing whereas …
[PDF][PDF] Natural genetic variation as a tool for discovery in Caenorhabditis nematodes
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
Nematode chromosomes
The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …
biology, including genetics, development, cell biology, and genomics. A major factor in the …
C. elegans as a model for inter-individual variation in metabolism
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic
background, nutritional input, microbiota and other environmental factors,,–. It is difficult to …
background, nutritional input, microbiota and other environmental factors,,–. It is difficult to …
Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0
Omics tools provide broad datasets for biological discovery. However, the computational
tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS …
tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS …