Inferring balancing selection from genome-scale data

BD Bitarello, DYC Brandt, D Meyer… - Genome biology and …, 2023 - academic.oup.com
The identification of genomic regions and genes that have evolved under natural selection is
a fundamental objective in the field of evolutionary genetics. While various approaches have …

From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation

KS Evans, MH van Wijk, PT McGrath, EC Andersen… - Trends in Genetics, 2021 - cell.com
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …

CaeNDR, the Caenorhabditis Natural Diversity Resource

TA Crombie, R McKeown, ND Moya… - Nucleic Acids …, 2024 - academic.oup.com
Studies of model organisms have provided important insights into how natural genetic
differences shape trait variation. These discoveries are driven by the growing availability of …

Ancient diversity in host-parasite interaction genes in a model parasitic nematode

L Stevens, I Martínez-Ugalde, E King, M Wagah… - Nature …, 2023 - nature.com
Host-parasite interactions exert strong selection pressures on the genomes of both host and
parasite. These interactions can lead to negative frequency-dependent selection, a form of …

The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages

R Cole, N Holroyd, A Tracey, M Berriman… - Nature …, 2023 - nature.com
Nematodes are important parasites of people and animals, and in natural ecosystems they
are a major ecological force. Strongyloides ratti is a common parasitic nematode of wild rats …

Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes

AA Teterina, JH Willis, M Lukac, R Jovelin… - PLoS …, 2023 - journals.plos.org
Caenorhabditis nematodes form an excellent model for studying how the mode of
reproduction affects genetic diversity, as some species reproduce via outcrossing whereas …

[PDF][PDF] Natural genetic variation as a tool for discovery in Caenorhabditis nematodes

EC Andersen, MV Rockman - Genetics, 2022 - academic.oup.com
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

Nematode chromosomes

PM Carlton, RE Davis, S Ahmed - Genetics, 2022 - academic.oup.com
The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

C. elegans as a model for inter-individual variation in metabolism

BW Fox, O Ponomarova, YU Lee, G Zhang, GE Giese… - Nature, 2022 - nature.com
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic
background, nutritional input, microbiota and other environmental factors,,–. It is difficult to …

Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0

DP Higgins, CM Weisman, DS Lui, FA D'Agostino… - Genetics, 2022 - academic.oup.com
Omics tools provide broad datasets for biological discovery. However, the computational
tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS …