Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to
explore changes in epigenome structure and their functional implications during …

The regulation of gene expression is mediated by interactions between chromatin and
protein complexes. The importance of where and when these interactions take place in the …

In eukaryotes, unlike in bacteria, gene order has typically been assumed to be random.
However, the first statistically rigorous analyses of complete genomes, together with the …

Research on the genomic architecture of speciation has increasingly revealed the
importance of structural variants (SVs) that affect the presence, abundance, position, and/or …

Iron is abundant universally. During the evolutionary processes, humans have selected iron
as a carrier of oxygen inside the body. However, iron works as a double‐edged sword, and …

Understanding nuclear architecture is indispensable for understanding the cell-type-
dependent orchestration of active and silent genes and other nuclear functions, such as …

Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …