Asymmetric aldol reactions are a powerful method for the construction of carbon–carbon
bonds in an enantioselective fashion. Historically this reaction has been performed in a …

The aldol reaction is one of the most important carbon–carbon bond formations in synthetic
organic chemistry. An enantioselective aldol reaction should provide an enantioenriched …

Polymer-supported chiral organocatalysts, as well as most other forms of immobilized
catalysts, are traditionally prepared by a postmodification approach where modified catalyst …

The aldol reaction is an excellent synthetic tool to construct β-hydroxy carbonyl skeletons.
The asymmetric version of this reaction has been developed for the synthesis of …

The development of enantioselective transformations has been the subject of numerous
research efforts. In recent years, a variety of efficient asymmetric catalysts for different …

A series of upper rim-functionalized calix [4] arene-based l-Proline derivatives have been
synthesized and employed for the enantioselective aldol reactions between cyclic ketones …

A series of amide-based bifunctional organocatalysts have been utilized in asymmetric
reactions. Prolinamide analogues have been designed to catalyze asymmetric reactions via …

Simple primary–tertiary diamines easily derived from natural primary amino acids have been
used to catalyze the aldol reactions in water. The 1 mol% of diamine catalyst is sufficient to …

Proline was reported as an enantioselective organocatalyst for direct asymmetric aldol
reaction in the early 1971 s by two independent groups of researchers and the reaction was …

Four prolinamide-based organocatalysts were readily synthesized and applied to the direct
asymmetric aldol reactions of ketones and aromatic aldehydes in brine. When 2, 4 …