Biofabrication of living structures with desired topology and functionality requires the
interdisciplinary effort of practitioners of the physical, life and engineering sciences. Such …

The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

Modeling clinically relevant tissue responses using cell models poses a significant
challenge for drug development, in particular for drug induced liver injury (DILI). This is …

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …

Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-
catenin signaling. Here, we used microarray analysis to identify two tumor subclasses …

Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis
of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron …

MicroRNAs (miRNAs) constitute a new class of regulators of gene expression. Among other
actions, miRNAs have been shown to control cell proliferation in development and cancer …

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide
hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron …

Differentiated cells can re-enter the cell cycle to repair tissue damage via a series of discrete
morphological and molecular stages coordinated by the cellular energetics regulator …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide,
with∼ 70% of cases resulting from hepatitis B and C viral infections, aflatoxin exposure …