The vast diversity of S100 proteins has demonstrated a multitude of biological correlations
with cell growth, cell differentiation and cell survival in numerous physiological and …

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been
discovered as a potent factor implicated in various inflammation-associated diseases …

Background & Aims S100A4 has been linked to the fibrosis of several organs due to its role
as a fibroblast-specific marker. However, the role of S100A4 itself in the development of …

The TGF-β/Smad3 signaling pathway is an important process in the pathogenesis of kidney
fibrosis. However, the molecular mechanisms are not completely elucidated. The current …

S100A4, an important member of the S100 family of proteins, is best known for its significant
role in promoting cancer progression and metastasis. In addition to its expression in tumors …

Tissue nonspecific alkaline phosphatase (TNAP) is expressed widely in different tissues,
modulating functions of metabolism and inflammation. However, the effect of TNAP on …

Fibroblast to myofibroblast transdifferentiation mediates numerous fibrotic disorders, such as
idiopathic pulmonary fibrosis (IPF). We have previously demonstrated that non-muscle …

Background Exercise training protects the heart against pathological cardiac remodeling
and confers cardioprotection from heart failure. However, the underlying mechanism is still …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a prevalence of 1 million
persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli and …

Background One of the most unique plants that have ever grown on the planet is Ginkgo
biloba L., a member of the Ginkgoaceae family with no close living relatives. The existence …