Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

KRAS mutations occur in a quarter of all of human cancers, yet no selective drug has been
approved to treat these tumors. Despite the recent development of drugs that block KRAS …

Aberrant activation of the RAS–RAF–MEK–ERK1/2 pathway occurs in more than 30% of
human cancers. As part of this pathway, MEK1 and MEK2 have crucial roles in …

First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52460698&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Porcine reproductive and respiratory syndrome (PRRS) causes decreased reproductive
performance in breeding animals and increased respiratory problems in growing animals …

Protein phosphorylation participates in the regulation of all fundamental biological
processes, and protein kinases have been intensively studied. However, while the focus …

The members of the HNRNPF/H family of heterogeneous nuclear RNA proteins—HNRNPF,
HNRNPH1, HNRNPH2, HNRNPH3, and GRSF1, are critical regulators of RNA maturation …