Anthraquinones as pharmacological tools and drugs

EM Malik, CE Müller - Medicinal research reviews, 2016 - Wiley Online Library
Abstract Anthraquinones (9, 10‐dioxoanthracenes) constitute an important class of natural
and synthetic compounds with a wide range of applications. Besides their utilization as …

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

V Brinkmann, A Billich, T Baumruker… - Nature reviews Drug …, 2010 - nature.com
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …

Immunological aspects of approved MS therapeutics

PS Rommer, R Milo, MH Han, S Satyanarayan… - Frontiers in …, 2019 - frontiersin.org
Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading
to disability in young adults. The outcome of the disease is unpredictable, and over time …

Nanomedicine and nanotheranostics: special focus on imaging of anticancer drugs induced cardiac toxicity

A Setia, RR Challa, B Vallamkonda, P Satti… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cardiotoxicity, the often-overlooked second leading cause of death in cancer patients, has
been associated with certain anticancer drugs. These drugs can induce cardiac damage …

A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)

J Chun, V Brinkmann - Discovery medicine, 2011 - pmc.ncbi.nlm.nih.gov
Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous
system (CNS) through demyelination and neurodegeneration. Until recently, major …

[HTML][HTML] The emerging role of neutrophil granulocytes in multiple sclerosis

T Woodberry, SE Bouffler, AS Wilson… - Journal of Clinical …, 2018 - mdpi.com
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a
strong autoimmune, neurodegenerative, and neuroinflammatory component. Most of the …

The heart as a target for xenobiotic toxicity: the cardiac susceptibility to oxidative stress

VM Costa, F Carvalho, JA Duarte… - Chemical research in …, 2013 - ACS Publications
The heart is a target organ for oxidative stress-related injuries. Because of its very high
energetic metabolic demand, the heart has the highest rate of production of reactive oxygen …

Requirement for safety monitoring for approved multiple sclerosis therapies: an overview

PS Rommer, UK Zettl, B Kieseier… - Clinical & …, 2014 - academic.oup.com
During the last two decades, treatment options for patients with multiple sclerosis (MS) have
broadened tremendously. All agents that are currently approved for clinical use have …

Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression?

A Geladaris, S Torke, MS Weber - CNS drugs, 2022 - Springer
In multiple sclerosis (MS) persisting disability can derive from acute relapses or,
alternatively, from slow and steady deterioration, termed chronic progression. Emerging data …

Bruton's tyrosine kinase as a promising therapeutic target for multiple sclerosis

D Saberi, A Geladaris, S Dybowski… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Multiple sclerosis (MS) is the most common demyelinating disease of the central
nervous system (CNS). Although there are several disease-modifying therapies that can …