[HTML][HTML] Eosinophils in health and disease: a state-of-the-art review
Eosinophils play a homeostatic role in the body's immune responses. These cells are
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …
Current understanding of asthma pathogenesis and biomarkers
N Habib, MA Pasha, DD Tang - Cells, 2022 - mdpi.com
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
OS Blomberg, L Spagnuolo, H Garner, L Voorwerk… - Cancer Cell, 2023 - cell.com
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
Cellular and molecular mechanisms of allergic asthma
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
Type 2 chronic inflammatory diseases: targets, therapies and unmet needs
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …
2 chronic inflammatory diseases has enabled the identification of compounds for more than …
The roles of eosinophils and interleukin‐5 in the pathophysiology of chronic rhinosinusitis with nasal polyps
P Gevaert, JK Han, SG Smith, AR Sousa… - International forum of …, 2022 - Wiley Online Library
Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally associated with eosinophilic
tissue infiltration linked to type 2 inflammation and characterized by elevated levels of …
tissue infiltration linked to type 2 inflammation and characterized by elevated levels of …
Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets
Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …
The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults
Y Renert-Yuval, E Del Duca, AB Pavel, M Fang… - Journal of Allergy and …, 2021 - Elsevier
Background Although atopic dermatitis (AD) often presents in infancy and persists into
adulthood, comparative characterization of AD skin among different pediatric age groups is …
adulthood, comparative characterization of AD skin among different pediatric age groups is …
Molecular targets for biological therapies of severe asthma
C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
bronchial obstruction, which is clinically expressed by different phenotypes driven by …