Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

Vitamin D deficiency has been associated with cholestatic liver disease such as primary
biliary cirrhosis. Some studies have suggested that cirrhosis can predispose patients to …

Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft
rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the …

Liver fibrosis is the most common final outcome for chronic liver diseases. The complex
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …

Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation
surgery. Understanding the mechanisms of liver ischemia reperfusion injury (IRI) and …

Endothelial cells are covered by a delicate meshwork of glycoproteins known as the
glycocalyx. Under normophysiological conditions the glycocalyx plays an active role in …

Hepatic ischemia and reperfusion injury are characterized by impaired autophagy,
mitochondrial dysfunction, and subsequent compromise of cellular homeostasis following …