Chiral chromatography method screening strategies: past, present and future

A Tarafder, L Miller - Journal of Chromatography A, 2021 - Elsevier
Method screening is an integral part of chromatographic method development for the
separation of racemates. Due to the highly complex retention mechanism of a chiral …

Recent advances in the enantioseparation promoted by ionic liquids and their resolution mechanisms

L Nie, A Yohannes, S Yao - Journal of Chromatography A, 2020 - Elsevier
More and more various chemical media are being applied in enantioseparation; among
them, ionic liquids (ILs) have attracted the long-term attention in this decade as green …

Bioassay, determination and separation of enantiomers of atenolol by direct and indirect approaches using liquid chromatography: A review

S Batra, R Bhushan - Biomedical Chromatography, 2018 - Wiley Online Library
Atenolol, a β‐adrenergic receptor antagonist, is a chiral compound used for the treatment of
cardiovascular diseases and to treat hypertension, coronary heart disease, arrhythmias …

Enantioseparation of six profenoid drugs by capillary electrophoresis with bovine serum albumin-modified gold nanoparticles as quasi-stationary phases

X Yun, L Wang, J Wang - Journal of Chromatography B, 2024 - Elsevier
Profenoid drugs are a kind of common non-steroidal anti-inflammatory drugs and their chiral
enantiomers often have huge differences in pharmacological activities. In this work, a novel …

Palladium‐and Iridium‐Catalyzed Deracemization of Allylic Oxygen Compounds with Oxygen Nucleophiles

HJ Gais - European Journal of Organic Chemistry, 2022 - Wiley Online Library
Allylic oxygen compounds (AOCs) are an important class of versatile building blocks in
natural and non‐natural product synthesis. Catalytic in‐situ deracemization is an attractive …

Thin-layer chromatographic enantioseparation of atenolol and propranolol using (S)-naproxen as chiral selector: direct and indirect approaches

VK Vashistha, R Bhushan - JPC–Journal of Planar Chromatography …, 2020 - Springer
Enantiomeric separation of (RS)-atenolol, and (RS)-propranolol has been achieved by thin-
layer chromatography (TLC) using both direct and indirect modes.(S)-naproxen, containing …

Highly sensitive novel fluorescent chiral probe possessing (S)-2-methylproline structures for the determination of chiral amino compounds by ultra-performance liquid …

XL Li, Y Han, Y Huang, X Sun, S **ao, JZ Min - Journal of Chromatography …, 2022 - Elsevier
We developed a novel fluorescent chiral probe, DBD-trans-2-methyl-L-proline (DBD-M-Pro),
which can be used to target recognition of amino functional groups using chiral resolution …

′ Ab Ovo′ Chiral Phases and Chiral Reagents for Liquid Chromatographic Separation and Isolation of Enantiomers

R Bhushan - The Chemical Record, 2022 - Wiley Online Library
The de‐novo approach of mixing chirally pure reagents or Cu (II)‐L‐amino acid complexes
in the slurry of silica gel for preparing TLC plates was reported from author's laboratory and …

Enantioselective Analysis and Separation of Two β‐Blockers via Derivatization Approach

Vinod, S Sharma, RVSR Pullabhotla, A Mittal - Chirality, 2025 - Wiley Online Library
Enantiomeric analysis of chiral drugs is very significant, as their enantiomers display
different pharmacological or toxicological behavior towards living systems. Among these …

[PDF][PDF] Chiral chromatography method screening

A Tarafder, L Miller - researchgate.net
Separation of enantiomers is an important process in many industries, especially pharma-73
ceutical drug discovery, due to different pharmacodynamic and pharmacokinetic activities of …