Engineering liposomal nanoparticles for targeted gene therapy
C Zylberberg, K Gaskill, S Pasley, S Matosevic - Gene therapy, 2017 - nature.com
Recent mechanistic studies have attempted to deepen our understanding of the process by
which liposome-mediated delivery of genetic material occurs. Understanding the …
which liposome-mediated delivery of genetic material occurs. Understanding the …
Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy
Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
considered to be one of the most efficient drug delivery platforms. Due to the prominent …
Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy
Aim: Rheumatoid arthritis is an autoimmune disease affecting the joints. Antiarthritic drugs
are given systemically, thereby exposing various healthy organs to these drugs, resulting in …
are given systemically, thereby exposing various healthy organs to these drugs, resulting in …
[PDF][PDF] Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids
Complex diseases such as cancer and microbial infections are multifactorial in nature with
numerous redundant signalling pathways involved in the disease development.[1–3] …
numerous redundant signalling pathways involved in the disease development.[1–3] …
Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
of the synovial tissue of the joints. Inadequately controlled disease may cause severe joint …
of the synovial tissue of the joints. Inadequately controlled disease may cause severe joint …
Recent Advances in Engineering Carriers for siRNA Delivery
RNA interference (RNAi) technology has been a promising treatment strategy for combating
intractable diseases. However, the applications of RNAi in clinical are hampered by …
intractable diseases. However, the applications of RNAi in clinical are hampered by …
Synthesis of low-molecular-weight antibacterial peptide mimetics based on dialkyl-and diacylamines
SM Filatova, ZG Denieva, UA Budanova… - Moscow university …, 2020 - Springer
This study is aimed at creating a number of derivatives of natural amino acids based on
dioctylamine and diethanolamine diesters with potential antibacterial activity. Simple and …
dioctylamine and diethanolamine diesters with potential antibacterial activity. Simple and …
α-Tocopherol-anchored gemini lipids with delocalizable cationic head groups: the effect of spacer length on DNA compaction and transfection properties
Understanding the role of structural units in cationic lipids used for gene delivery is essential
in designing efficient gene delivery vehicles. Herein, we report a systematic structure …
in designing efficient gene delivery vehicles. Herein, we report a systematic structure …
Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations
Introduction Designing safe and effective nucleic acid delivery nanosystems presents a
challenge that requires a good understanding of various biological barriers, whose impact is …
challenge that requires a good understanding of various biological barriers, whose impact is …
Multifunctional neomycin-triazine-based cationic lipids for gene delivery with antibacterial properties
Cationic lipids (CLs) have gained significant attention among nonviral gene delivery vectors
due to their ease of synthesis and functionalization with multivalent moieties. In particular …
due to their ease of synthesis and functionalization with multivalent moieties. In particular …