ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Neuroplasticity refers to the ability of the brain to reorganize and modify its neural
connections in response to environmental stimuli, experience, learning, injury, and disease …

As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …

Exercise has been shown to benefit brain structure and function, particularly in aging
populations. However, the mechanisms by which exercise exerts its effects, especially in …

Medical imaging has enormous potential for early disease prediction, but is impeded by the
difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to …

Delineating the association of age and cortical thickness in healthy individuals is critical
given the association of cortical thickness with cognition and behavior. Previous research …

Quantitative susceptibility map** (QSM) is a magnetic resonance imaging (MRI) technique
that can assess the magnetic properties of cerebral iron in vivo. Although brain iron is …

Little is still known about the neuroanatomical substrates related to changes in specific
cognitive abilities in the course of healthy aging, and the existing evidence is predominantly …