The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat

PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

AA Parkhitko, E Filine, SE Mohr, A Moskalev… - Ageing research …, 2020 - Elsevier
Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Review of molecular and biochemical responses during stress induced stimulation and hormesis in insects

RR Rix, GC Cutler - Science of the Total Environment, 2022 - Elsevier
The biphasic hormetic response to stress, defined by low-dose stimulation and high-dose
inhibition is frequently observed in insects. Various molecular and biochemical responses …

[HTML][HTML] Carob (Ceratonia siliqua) as Functional Feed Is Beneficial in Yellow Mealworm (Tenebrio molitor) Rearing: Evidence from Growth, Antioxidant Status and …

E Antonopoulou, N Panteli, K Feidantsis, M Mastoraki… - Antioxidants, 2022 - mdpi.com
In terms of sustainability and circular economy, agricultural by-products may be efficiently
reused in insects' rearing for high-quality protein sources in human diet and animal feeds …

Different dietary protein levels affect flesh quality, fatty acids and alter gene expression of Nrf2-mediated antioxidant enzymes in the muscle of grass carp …

J Xu, L Feng, WD Jiang, P Wu, Y Liu, J Jiang… - Aquaculture, 2018 - Elsevier
This study investigated the effects of dietary protein levels on the flesh quality, fatty acids,
antioxidant capacity and antioxidant-related signalling molecule gene expression in the …

Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin

W Wei, Q Dong, W Jiang, Y Wang, Y Chen, T Han… - Metabolic Brain …, 2021 - Springer
The present study was designed to evaluate the role of cAMP-PKA-CREB signaling in
mediating the neuroprotective effects of curcumin against DCAA-induced oxidative stress …

Hsp27, a potential EcR target, protects nonylphenol-induced cellular and organismal toxicity in Drosophila melanogaster

S Dwivedi, LC D'Souza, NG Shetty, SV Raghu… - Environmental …, 2022 - Elsevier
Deciphering the potential mechanism of chemical-induced toxicity enables us to alleviate
the cellular and organismal dysfunction. The environmental presence of nonylphenol …

Mitophagy-promoting agents and their ability to promote healthy-aging

V Srivastava, E Gross - Biochemical Society Transactions, 2023 - portlandpress.com
The removal of damaged mitochondrial components through a process called mitochondrial
autophagy (mitophagy) is essential for the proper function of the mitochondrial network …

[HTML][HTML] Naturally occurring emerging contaminants: Where to hide?

H Miraji, M Eunice, A Ripanda, F Ngassapa, O Chande - HydroResearch, 2023 - Elsevier
Water disinfection by-products (DBPs) are among insitu-generated emerging contaminants
(ECs) during water disinfection. Although water disinfectants control acute risks through …

Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis

V Bakalov, L Reyes-Uribe, R Deshpande, AL Maloy… - PLoS …, 2020 - journals.plos.org
Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay
and these long-term sequelae are due in part to unresolved inflammation. Metabolic shift …