Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

The gene-expression profile of aggressive cutaneous and uveal melanoma cells resembles
that of an undifferentiated, embryonic-like cell. The plasticity of certain types of cancer cell …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

Background—Experimental data suggest that bone marrow–derived cells may contribute to
the healing of myocardial infarction (MI). For this reason, we analyzed 10 patients who were …

Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in
heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes …

Cardiac myocytes have been traditionally regarded as terminally differentiated cells that
adapt to increased work and compensate for disease exclusively through hypertrophy …

The concept of regenerating diseased myocardium by implantation of tissue-engineered
heart muscle is intriguing, but convincing evidence is lacking that heart tissues can be …

Recent progress in cell transplantation therapy to repair impaired hearts has encouraged
further attempts to bioengineer 3-dimensional (3-D) heart tissue from cultured …

Human embryonic stem cells have the potential to differentiate into various cell types and,
thus, may be useful as a source of cells for transplantation or tissue engineering. We …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …