Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes

M Gulino, D Kim, S Pané, SD Santos… - Frontiers in …, 2019 - frontiersin.org
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …

Flexible, penetrating brain probes enabled by advances in polymer microfabrication

A Weltman, J Yoo, E Meng - Micromachines, 2016 - mdpi.com
The acquisition of high-fidelity, long-term neural recordings in vivo is critically important to
advance neuroscience and brain–machine interfaces. For decades, rigid materials such as …

Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo

A Canales, X Jia, UP Froriep, RA Koppes… - Nature …, 2015 - nature.com
Brain function depends on simultaneous electrical, chemical and mechanical signaling at
the cellular level. This multiplicity has confounded efforts to simultaneously measure or …

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

JK Nguyen, DJ Park, JL Skousen… - Journal of neural …, 2014 - iopscience.iop.org
Objective. The mechanisms underlying intracortical microelectrode encapsulation and
failure are not well understood. A leading hypothesis implicates the role of the mechanical …

Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording

TDY Kozai, K Catt, X Li, ZV Gugel, VT Olafsson… - Biomaterials, 2015 - Elsevier
Penetrating intracortical electrode arrays that record brain activity longitudinally are powerful
tools for basic neuroscience research and emerging clinical applications. However …

Relationship between intracortical electrode design and chronic recording function

L Karumbaiah, T Saxena, D Carlson, K Patil, R Patkar… - Biomaterials, 2013 - Elsevier
Intracortical electrodes record neural signals directly from local populations of neurons in the
brain, and conduct them to external electronics that control prosthetics. However, the …

Explant analysis of Utah electrode arrays implanted in human cortex for brain-computer-interfaces

K Woeppel, C Hughes, AJ Herrera, JR Eles… - … in Bioengineering and …, 2021 - frontiersin.org
Brain-computer interfaces are being developed to restore movement for people living with
paralysis due to injury or disease. Although the therapeutic potential is great, long-term …

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

SL Norman, D Maresca, VN Christopoulos, WS Griggs… - Neuron, 2021 - cell.com
New technologies are key to understanding the dynamic activity of neural circuits and
systems in the brain. Here, we show that a minimally invasive approach based on …

Mechanical and biological interactions of implants with the brain and their impact on implant design

D Prodanov, J Delbeke - Frontiers in neuroscience, 2016 - frontiersin.org
Neural prostheses have already a long history and yet the cochlear implant remains the only
success story about a longterm sensory function restoration. On the other hand, neural …

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size

CAR Chapman, H Chen, M Stamou… - … applied materials & …, 2015 - ACS Publications
Designing neural interfaces that maintain close physical coupling of neurons to an electrode
surface remains a major challenge for both implantable and in vitro neural recording …