Inflammaging and osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Epigenetics, DNA damage, and aging
C Soto-Palma, LJ Niedernhofer… - The Journal of …, 2022 - Am Soc Clin Investig
Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …
abundance of several types of chromatin changes. The abundance of DNA lesions …
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
S Ji, M ** the epigenetic modifications of DNA and RNA
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …
respectively. The interest in understanding the various biological functions of DNA and RNA …
A deep learning framework with an embedded-based feature selection approach for the early detection of the Alzheimer's disease
Ageing is associated with various ailments including Alzheimer's disease (AD), which is a
progressive form of dementia. AD symptoms develop over a period of years and …
progressive form of dementia. AD symptoms develop over a period of years and …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
Origins of human disease: the chrono-epigenetic perspective
ES Oh, A Petronis - Nature Reviews Genetics, 2021 - nature.com
Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …
features that cannot be explained by genetic and environmental factors. However …
[HTML][HTML] Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging …
O Demidenko, D Barardo, V Budovskii… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The search continues for possible interventions that delay and/or reverse biological aging,
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …