Fragmentation methods: A route to accurate calculations on large systems

MS Gordon, DG Fedorov, SR Pruitt… - Chemical …, 2012 - ACS Publications
Theoretical chemists have always strived to perform quantum mechanics (QM) calculations
on larger and larger molecules and molecular systems, as well as condensed phase …

Energy-based molecular fragmentation methods

MA Collins, RPA Bettens - Chemical reviews, 2015 - ACS Publications
1.1 Objectives A major objective of theoretical and computational chemistry is the calculation
of the energy and properties of molecules, so that chemical reactivity and material properties …

QM/MM: what have we learned, where are we, and where do we go from here?

H Lin, DG Truhlar - Theoretical Chemistry Accounts, 2007 - Springer
This paper briefly reviews the current status of the most popular methods for combined
quantum mechanical/molecular mechanical (QM/MM) calculations, including their …

Extending the power of quantum chemistry to large systems with the fragment molecular orbital method

DG Fedorov, K Kitaura - The Journal of Physical Chemistry A, 2007 - ACS Publications
Following the brief review of the modern fragment-based methods and other approaches to
perform quantum-mechanical calculations of large systems, the theoretical development of …

The effective fragment potential: a general method for predicting intermolecular interactions

MS Gordon, L Slipchenko, H Li, JH Jensen - Annual reports in …, 2007 - Elsevier
Publisher Summary The interactions between molecules and molecular systems play key
roles in many important phenomena in chemistry, biological sciences, materials science and …

Frozen density functional free energy simulations of redox proteins: computational studies of the reduction potential of plastocyanin and rusticyanin

MHM Olsson, G Hong, A Warshel - Journal of the American …, 2003 - ACS Publications
The evaluation of reduction potentials of proteins by ab initio approaches presents a major
challenge for computational chemistry. This is addressed in the present investigation by …

A parallelized integral-direct second-order Møller–Plesset perturbation theory method with a fragment molecular orbital scheme

Y Mochizuki, T Nakano, S Koikegami… - Theoretical Chemistry …, 2004 - Springer
We propose a parallelized integral-direct algorithm of the second-order Møller–Plesset
perturbation theory (MP2) as a size-consistent correlated method. The algorithm is a …

Extension of the effective fragment potential method to macromolecules

PK Gurunathan, A Acharya, D Ghosh… - The Journal of …, 2016 - ACS Publications
The effective fragment potential (EFP) approach, which can be described as a nonempirical
polarizable force field, affords an accurate first-principles treatment of noncovalent …

Constant pH replica exchange molecular dynamics in biomolecules using a discrete protonation model

Y Meng, AE Roitberg - Journal of chemical theory and …, 2010 - ACS Publications
A constant pH replica exchange molecular dynamics (REMD) method is proposed and
implemented to improve coupled protonation and conformational state sampling. By mixing …

Prediction and Rationalization of Protein pKa Values Using QM and QM/MM Methods

JH Jensen, H Li, AD Robertson… - The Journal of Physical …, 2005 - ACS Publications
We describe the development and application of a computational method for the prediction
and rationalization of p K a values of ionizable residues in proteins, based on ab initio …