Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Human genetics and epigenetics of alcohol use disorder
Alcohol use disorder (AUD) is a prominent contributor to global morbidity and mortality. Its
complex etiology involves genetics, epigenetics, and environmental factors. We review …
complex etiology involves genetics, epigenetics, and environmental factors. We review …
MESuSiE enables scalable and powerful multi-ancestry fine-map** of causal variants in genome-wide association studies
B Gao, X Zhou - Nature Genetics, 2024 - nature.com
Fine-map** in genome-wide association studies attempts to identify causal SNPs from a
set of candidate SNPs in a local genomic region of interest and is commonly performed in …
set of candidate SNPs in a local genomic region of interest and is commonly performed in …
Fine-map** causal tissues and genes at disease-associated loci
Complex diseases often have distinct mechanisms spanning multiple tissues. We propose
tissue–gene fine-map** (TGFM), which infers the posterior inclusion probability (PIP) for …
tissue–gene fine-map** (TGFM), which infers the posterior inclusion probability (PIP) for …
Genetic architecture of routinely acquired blood tests in a British South Asian cohort
Understanding the genetic basis of routinely-acquired blood tests can provide insights into
several aspects of human physiology. We report a genome-wide association study of 42 …
several aspects of human physiology. We report a genome-wide association study of 42 …
Shared genetic architectures of educational attainment in East Asian and European populations
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …
ability, is associated with various health and social outcomes. Previous genome-wide …
Genetic control of DNA methylation is largely shared across European and East Asian populations
DNA methylation is an ideal trait to study the extent of the shared genetic control across
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
Whole genome association testing in 333,100 individuals across three biobanks identifies rare non-coding single variant and genomic aggregate associations with …
The role of rare non-coding variation in complex human phenotypes is still largely unknown.
To elucidate the impact of rare variants in regulatory elements, we performed a whole …
To elucidate the impact of rare variants in regulatory elements, we performed a whole …
Human height: a model common complex trait
M Conery, SFA Grant - Annals of human biology, 2023 - Taylor & Francis
Context Like other complex phenotypes, human height reflects a combination of
environmental and genetic factors, but is notable for being exceptionally easy to measure …
environmental and genetic factors, but is notable for being exceptionally easy to measure …