A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

Postoperative anatomical reconstruction and prevention of local recurrence after tumor
resection are two vital clinical challenges in osteosarcoma treatment. A three-dimensional …

Statins have been shown to inhibit cell proliferation in vitro and tumor growth in animal
models. Various studies have also shown a decreased cancer-specific mortality rate in …

Evidence from preclinical studies suggests that the competitive HMG-CoA reductase
(HMGCR) inhibitors universally known as' statins,'in addition to being powerful drugs that …

Recently, Simvastatin (SIM) is received notable attention due to its anti-cancer properties.
However, the lipophilicity feature of SIM restricted its application as a chemotherapy agent …

The mevalonate pathway provides sterols for membrane structure and nonsterol
intermediates for the post-translational modification and membrane anchorage of growth …

Statins are long known class of medicines and the most frequently prescribed drugs in
cardiovascular pharmacotherapy, widely ordered not only in patients suffering from …

Rab GTPases are critical regulators of protein trafficking in the cell. To ensure proper cellular
localization and function, Rab proteins must undergo a posttranslational modification …

Despite increasing knowledge on oral and esophageal squamous cell carcinoma (OSCC
and ESCC), specific medicines against both have not yet been developed. Here, we aimed …