Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both
physiological and pathological conditions, nearly all types of cells can release exosomes …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is
the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Cancer stem cells (CSCs) are subpopulations of tumor cells with the ability to self-renew,
differentiate, and initiate and maintain tumor growth, and they are considered to be the main …

Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic,
recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying …

Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogeneous
cell population is a daunting challenge. Here, we show that microfluidic devices can be used …

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo-, radio-and immuno-resistance. Understanding the mechanism of …

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of
cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism …