Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Cell signaling by receptor tyrosine kinases
J Schlessinger - Cell, 2000 - cell.com
(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …
Receptor dimerization is of most fundamental cellular processes including the further …
ERK1/2 MAP kinases: structure, function, and regulation
R Roskoski Jr - Pharmacological research, 2012 - Elsevier
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
Cell signaling mechanisms often transmit information via posttranslational protein
modifications, most importantly reversible protein phosphorylation. Here we develop and …
modifications, most importantly reversible protein phosphorylation. Here we develop and …
[HTML][HTML] Genistein, a specific inhibitor of tyrosine-specific protein kinases.
T Akiyama, J Ishida, S Nakagawa, H Ogawara… - Journal of Biological …, 1987 - Elsevier
Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-
src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was …
src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was …
[HTML][HTML] Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
M Amano, M Ito, K Kimura, Y Fukata, K Chihara… - Journal of Biological …, 1996 - ASBMB
The small GTPase Rho is implicated in physiological functions associated with actin-myosin
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently …
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently …
Serine/threonine phosphatases: mechanism through structure
Y Shi - Cell, 2009 - cell.com
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
Mechanisms of specificity in protein phosphorylation
A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
How does the extracellular matrix direct gene expression?
MJ Bissell, HG Hall, G Parry - Journal of theoretical biology, 1982 - Elsevier
Based on the existing literature, a model is presented that postulates a “dynamic reciprocity”
between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the …
between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the …