Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical
deficits, including permanent or progressive disabilities of sensory, motor and autonomic …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Microglia are brain-resident macrophages that contribute to central nervous system (CNS)
development, maturation, and preservation. Here, we examine the consequences of …

Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis
optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells …

Microglia replacement strategies are increasingly being considered for the treatment of
primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and …

Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the
degeneration of neurons and their connections that drives progressive disability in …

Recent single-cell RNA sequencing studies have revealed distinct microglial states in
development and disease. These include proliferative-region-associated microglia (PAMs) …

Demyelination in the central nervous system (CNS) is a hallmark of many
neurodegenerative diseases such as multiple sclerosis (MS) and others. Here, we studied …

Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …

Nanomedicine is a newer, promising approach to promote neuroprotection,
neuroregeneration, and modulation of the blood–brain barrier. This review includes the …