Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …

Extracellular vesicles as an emerging frontier in spinal cord injury pathobiology and therapy

D Dutta, N Khan, J Wu, SM Jay - Trends in neurosciences, 2021 - cell.com
Extracellular vesicles (EVs) are membrane-delimited particles that are secreted by nearly all
cell types. EVs mediate crucial physiological functions and pathophysiological processes in …

[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …

Y Li, RM Ritzel, N Khan, T Cao, J He, Z Lei… - Theranostics, 2020 - ncbi.nlm.nih.gov
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …

Spinal cord injury-induced cognitive impairment: A narrative review

OV Alcántar-Garibay… - Neural Regeneration …, 2022 - journals.lww.com
Spinal cord injury is a serious damage to the spinal cord that can lead to life-long disability.
Based on its etiology, spinal cord injury can be classified as traumatic or non-traumatic …

[HTML][HTML] Neuropathic pain after spinal cord injury: challenges and research perspectives

R Shiao, CA Lee-Kubli - Neurotherapeutics, 2018 - Elsevier
Neuropathic pain is a debilitating consequence of spinal cord injury (SCI) that remains
difficult to treat because underlying mechanisms are not yet fully understood. In part, this is …

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

X Sun, ZB Jones, X Chen, L Zhou, KF So… - Journal of …, 2016 - Springer
Spinal cord injury (SCI) is a devastating event that results in significant physical disabilities
for affected individuals. Apart from local injury within the spinal cord, SCI patients develop a …

[HTML][HTML] Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential

NZ Khan, T Cao, J He, RM Ritzel, Y Li, RJ Henry… - Brain, behavior, and …, 2021 - Elsevier
Extracellular vesicles (EVs) have been implicated mechanistically in the pathobiology of
neurodegenerative disorders, including central nervous system injury. However, the role of …

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

S Liu, C Sarkar, M Dinizo, AI Faden, EY Koh… - Cell death & …, 2015 - nature.com
Autophagy is a catabolic mechanism facilitating degradation of cytoplasmic proteins and
organelles in a lysosome-dependent manner. Autophagy flux is necessary for normal …

Cognitive impairment and mood states after spinal cord injury

A Craig, R Guest, Y Tran, J Middleton - Journal of Neurotrauma, 2017 - liebertpub.com
Spinal cord injury (SCI) is believed to be associated with high rates of cognitive impairment,
which can result in complications in recovery. This study concerned two groups of adults …

Dementia, depression, and associated brain inflammatory mechanisms after spinal cord injury

Y Li, T Cao, RM Ritzel, J He, AI Faden, J Wu - Cells, 2020 - mdpi.com
Evaluation of the chronic effects of spinal cord injury (SCI) has long focused on sensorimotor
deficits, neuropathic pain, bladder/bowel dysfunction, loss of sexual function, and emotional …