The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …

The HER-2/neu oncogene is a member of the erb B-like oncogene family, and is related to,
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …

Carcinoma of the breast and ovary account for one-third of all cancers occurring in women
and together are responsible for approximately one-quarter of cancer-related deaths in …

The previously established classification (Yarden and Ullrich, 1988) has been extended by
recently described receptor tyrosine kinases such as HER3/c-erbB-3 (Kraus et al., 1989) IRR …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

MULTIPLE endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer
syndrome that affects tissues derived from neural ectoderm. It is characterized by medullary …

Overexpression and amplification of the neu (c-erbB2, ERBB2) protooncogene have been
implicated in the development of aggressive human breast cancer. To directly assess the …

Structural features of v‐kit, the oncogene of HZ4 feline sarcoma virus, suggested that this
gene arose by transduction and truncation of cellular sequences. Complementary DNA …