[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
Emotion and the prefrontal cortex: An integrative review.
The prefrontal cortex (PFC) plays a critical role in the generation and regulation of emotion.
However, we lack an integrative framework for understanding how different emotion-related …
However, we lack an integrative framework for understanding how different emotion-related …
First-in-human prediction of chronic pain state using intracranial neural biomarkers
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …
and disability. Pain severity is often measured through subjective report, while objective …
Neural circuit basis of placebo pain relief
Placebo effects are notable demonstrations of mind–body interactions,. During pain
perception, in the absence of any treatment, an expectation of pain relief can reduce the …
perception, in the absence of any treatment, an expectation of pain relief can reduce the …
The neuroscience of placebo effects: connecting context, learning and health
Placebo effects are beneficial effects that are attributable to the brain–mind responses to the
context in which a treatment is delivered rather than to the specific actions of the drug. They …
context in which a treatment is delivered rather than to the specific actions of the drug. They …
Descending pain modulation and chronification of pain
MH Ossipov, K Morimura, F Porreca - Current opinion in …, 2014 - journals.lww.com
Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …
have advanced our understanding of brain circuits that modulate pain. Descending pain …
Mindfulness meditation-based pain relief employs different neural mechanisms than placebo and sham mindfulness meditation-induced analgesia
Mindfulness meditation reduces pain in experimental and clinical settings. However, it
remains unknown whether mindfulness meditation engages pain-relieving mechanisms …
remains unknown whether mindfulness meditation engages pain-relieving mechanisms …
[HTML][HTML] The ecology of human fear: survival optimization and the nervous system
We propose a Survival Optimization System (SOS) to account for the strategies that humans
and other animals use to defend against recurring and novel threats. The SOS attempts to …
and other animals use to defend against recurring and novel threats. The SOS attempts to …
Emotional processing in anterior cingulate and medial prefrontal cortex
Negative emotional stimuli activate a broad network of brain regions, including the medial
prefrontal (mPFC) and anterior cingulate (ACC) cortices. An early influential view …
prefrontal (mPFC) and anterior cingulate (ACC) cortices. An early influential view …
Mindfulness meditation–based pain relief: a mechanistic account
Pain is a multidimensional experience that involves interacting sensory, cognitive, and
affective factors, rendering the treatment of chronic pain challenging and financially …
affective factors, rendering the treatment of chronic pain challenging and financially …