Objectives: In 2011, the US Environmental Protection Agency initiated the NexGen project to
develop a new paradigm for the next generation of risk science. Methods: The NexGen …

Worldwide, most children face marginalization and societal inequities to varying degrees.
For developmental science to have both scientific and societal value, scientists must account …

The developmental origin of health and disease hypothesis states that adverse fetal and
early childhood exposures can predispose to obesity, cardiovascular, and …

Health risks in both animals and humans are associated with chronic exposures to levels of
trace elements (TE) eliciting toxic and/or antinutritional effects, including excess exposures …

Understanding differential disease susceptibility requires new tools to quantify the
cumulative effects of environmental stress. Evidence suggests that social, physical, and …

Objective Human papilloma virus (HPV) positive and HPV negative head and neck
squamous cell cancer (HNSCC) are biologically distinct with a prognostic advantage for …

A tissue field of somatic genetic alterations precedes the histopathological phenotypic
changes of carcinoma. Genomic changes could be of potential use in the diagnosis and …

Molecular targeted therapy in head and neck squamous cell carcinoma (HNSCC) continues
to make strides, and holds much promise. Cetuximab remains the sole US FDA-approved …

One of the major challenges in chemical safety assessment is prioritisation of the large
number of chemicals in commerce. Over the past five years, a new tiered approach to …

During the past decade, there has been a significant increase in knowledge regarding the
molecular biology and epigenetics of head and neck carcer. Despite much effort to identify …