Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
3′ UTR heterogeneity and cancer progression
JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …
through various processes, including RNA modifications such as RNA editing, m 6 A …
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes
The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and
hyperactivation of the TLRs and subsequent inflammatory consequences have been …
hyperactivation of the TLRs and subsequent inflammatory consequences have been …
Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Mechanisms of DNA methylation regulatory function and crosstalk with histone lysine methylation
BM Tibben, SB Rothbart - Journal of Molecular Biology, 2024 - Elsevier
DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …
[LIBRO][B] RNA, the epicenter of genetic information
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
Epigenetic regulation of genomic stability by vitamin C
JP Brabson, T Leesang, S Mohammad… - Frontiers in genetics, 2021 - frontiersin.org
DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
RNA helicase-dependent gene loo** impacts messenger RNA processing
S Terrone, J Valat, N Fontrodona, G Giraud… - Nucleic Acids …, 2022 - academic.oup.com
Abstract DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several
aspects of gene expression, especially transcription and splicing, through incompletely …
aspects of gene expression, especially transcription and splicing, through incompletely …