The senescence journey in cancer immunoediting
Cancer progression is continuously controlled by the immune system which can identify and
destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system …
destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system …
Endogenous retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS pathway directly control senescence and aging as a consequence of ERV De-repression?
E Di Giorgio, LE Xodo - Frontiers in immunology, 2022 - frontiersin.org
Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common
feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer incidence …
feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer incidence …
Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces …
E Di Giorgio, L Ranzino, V Tolotto, E Dalla… - Cell Death & …, 2024 - nature.com
An important epigenetic switch marks the onset and maintenance of senescence. This
allows transcription of the genetic programs that arrest the cell cycle and alter the …
allows transcription of the genetic programs that arrest the cell cycle and alter the …
The histone code of senescence
Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease
F Macciardi, M Giulia Bacalini, R Miramontes… - GeroScience, 2022 - Springer
Recent reports have suggested that the reactivation of otherwise transcriptionally silent
transposable elements (TEs) might induce brain degeneration, either by dysregulating the …
transposable elements (TEs) might induce brain degeneration, either by dysregulating the …
T-cell immunity against senescence: potential role and perspectives
The development of age-associated diseases is related to the accumulation of senescent
cells in the body. These are old non-functional cells with impaired metabolism, which are …
cells in the body. These are old non-functional cells with impaired metabolism, which are …
Shared enhancer gene regulatory networks between wound and oncogenic programs
S Floc'hlay, R Balaji, D Stanković, VM Christiaens… - Elife, 2023 - elifesciences.org
Wound response programs are often activated during neoplastic growth in tumors. In both
wound repair and tumor growth, cells respond to acute stress and balance the activation of …
wound repair and tumor growth, cells respond to acute stress and balance the activation of …
A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence
Aging and senescence are characterized by pervasive transcriptional dysfunction, including
increased expression of transposons and introns. Our aim was to elucidate mechanisms …
increased expression of transposons and introns. Our aim was to elucidate mechanisms …
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence
H Tang, J Yang, J Xu, W Zhang, A Geng, Y Jiang… - EMBO …, 2024 - embopress.org
As a hallmark of senescent cells, the derepression of Long Interspersed Elements 1 (LINE1)
transcription results in accumulated LINE1 cDNA, which triggers the secretion of the …
transcription results in accumulated LINE1 cDNA, which triggers the secretion of the …
Transposons: Unexpected players in cancer
RK Pradhan, W Ramakrishna - Gene, 2022 - Elsevier
Transposons are repetitive DNA sequences encompassing about half of the human
genome. They play a vital role in genome stability maintenance and contribute to genomic …
genome. They play a vital role in genome stability maintenance and contribute to genomic …