The role of trace elements and minerals in osteoporosis: a review of epidemiological and laboratory findings

AV Skalny, M Aschner, EV Silina, VA Stupin… - Biomolecules, 2023 - mdpi.com
The objective of the present study was to review recent epidemiological and clinical data on
the association between selected minerals and trace elements and osteoporosis, as well as …

Progress of signaling pathways, stress pathways and epigenetics in the pathogenesis of skeletal fluorosis

L Qiao, X Liu, Y He, J Zhang, H Huang, W Bian… - International journal of …, 2021 - mdpi.com
Fluorine is widely dispersed in nature and has multiple physiological functions. Although it is
usually regarded as an essential trace element for humans, this view is not held universally …

Enamel phenotypes: genetic and environmental determinants

JT Wright - Genes, 2023 - mdpi.com
Dental enamel is a specialized tissue that has adapted over millions of years of evolution to
enhance the survival of a variety of species. In humans, enamel evolved to form the exterior …

Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

AH Nagendra, B Bose, S Shenoy P - Molecular Biology Reports, 2021 - Springer
Fluoride is a natural element essential in minute quantities in human's to maintain dental
and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride …

Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio)

M Li, J Cao, Y Zhao, P Wu, X Li, F Khodaei, Y Han… - Chemosphere, 2020 - Elsevier
Previous studies have shown that waterborne fluoride exposure has adverse effects on the
reproductive system of zebrafish. However, the underlying toxic mechanisms were still not …

[HTML][HTML] Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats

H Li, J Fan, Y Zhao, J Yang, H Xu, RK Manthari… - Ecotoxicology and …, 2021 - Elsevier
Long-term excessive intake of fluoride (F) can cause osseous and non-osseous damage.
The kidney is the main fluoride excretion organ of the body. This study aimed to explore …

[HTML][HTML] Molecular basis of fluoride toxicities: beyond benefits and implications in human disorders

P Pal, NK Jha, D Pal, SK Jha, U Anand… - Genes & …, 2023 - Elsevier
Detrimental impacts of fluoride have become a global concern for several decades. Despite
its beneficial role which is restricted only in skeletal tissues, deleterious effects are also …

[PDF][PDF] Fluoride contamination, toxicity and its potential therapeutic agents

P Rajak, S Roy, S Khatun, M Mandi… - Toxicology …, 2023 - researchgate.net
Fluoride is the thirteenth most abundant element in the earth's crust. It is highly
electronegative and distributed ubiquitously in nature. During weathering of rocks and soil …

Advances in nutritional epigenetics—A fresh perspective for an old idea. Lessons learned, limitations, and future directions

L Sedley - Epigenetics Insights, 2020 - journals.sagepub.com
Nutritional epigenetics is a rapidly expanding field of research, and the natural modulation of
the genome is a non-invasive, sustainable, and personalized alternative to gene-editing for …

Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice

T Wang, H Li, Y Li, M Li, H Zhao, W Zhang… - Science of The Total …, 2024 - Elsevier
As an environmental pollutant, fluoride-induced liver damage is directly linked to
mitochondrial alteration and oxidative stress. Selenium's antioxidant capacity has been …