Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Novel non-nucleic acid targets detection strategies based on CRISPR/Cas toolboxes: A review

X Cheng, Y Li, J Kou, D Liao, W Zhang, L Yin… - Biosensors and …, 2022 - Elsevier
Various non-nucleic acid targets (ions, small molecules, polysaccharides, peptides/proteins/
enzymes, cells, transcription factors) are important biomarkers. They play important roles in …

Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants

NL Welch, M Zhu, C Hua, J Weller, ME Mirhashemi… - Nature medicine, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has demonstrated a clear
need for high-throughput, multiplexed and sensitive assays for detecting severe acute …

SERS-based CRISPR/Cas assay on microfluidic paper analytical devices for supersensitive detection of pathogenic bacteria in foods

J Zhuang, Z Zhao, K Lian, L Yin, J Wang, S Man… - Biosensors and …, 2022 - Elsevier
Rapid and point-of-need (PON) detection of bacteria is crucial to directly provide rapid and
reliable diagnostics information during on-site tests, allowing more room for taking proactive …

CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics

R Bruch, J Baaske, C Chatelle, M Meirich… - Advanced …, 2019 - Wiley Online Library
Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for
multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be …

Ultra-sensitive and high-throughput CRISPR-p owered COVID-19 diagnosis

Z Huang, D Tian, Y Liu, Z Lin, CJ Lyon, W Lai… - Biosensors and …, 2020 - Elsevier
Recent research suggests that SARS-CoV-2-infected individuals can be highly infectious
while asymptomatic or pre-symptomatic, and that an infected person may infect 5.6 other …

A smartphone-read ultrasensitive and quantitative saliva test for COVID-19

B Ning, T Yu, S Zhang, Z Huang, D Tian, Z Lin… - Science …, 2021 - science.org
Point-of-care COVID-19 assays that are more sensitive than the current RT-PCR (reverse
transcription polymerase chain reaction) gold standard assay are needed to improve …

The impact of biosensing in a pandemic outbreak: COVID-19

E Morales-Narváez, C Dincer - Biosensors and Bioelectronics, 2020 - Elsevier
COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI
century. In this opinionated review, we underscore the crucial role of biosensing to handle …

CRISPR‐Cas‐based detection for food safety problems: Current status, challenges, and opportunities

Y Li, S Man, S Ye, G Liu, L Ma - Comprehensive Reviews in …, 2022 - Wiley Online Library
Food safety is one of the biggest public issues occurring around the world. Microbiological,
chemical, and physical hazards can lead to food safety issues, which may occur at all stages …

Amplification‐free detection of SARS‐CoV‐2 and respiratory syncytial virus using CRISPR Cas13a and graphene field‐effect transistors

H Li, J Yang, G Wu, Z Weng, Y Song… - Angewandte …, 2022 - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐
associated (Cas) systems have recently received notable attention for their applications in …