[HTML][HTML] Insulin/insulin-like growth factor signaling in C. elegans
The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology
That senescence is rarely, if ever, observed in natural populations is an oft-quoted fallacy
within bio-gerontology. We identify the roots of this fallacy in the otherwise seminal works of …
within bio-gerontology. We identify the roots of this fallacy in the otherwise seminal works of …
Why do we age?
The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into
the mechanisms underlying the complex cellular and molecular changes that contribute to …
the mechanisms underlying the complex cellular and molecular changes that contribute to …
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Caloric restriction extends lifespan in numerous species. In the budding yeast
Saccharomyces cerevisiae this effect requires Sir2 (ref.), a member of the sirtuin family of …
Saccharomyces cerevisiae this effect requires Sir2 (ref.), a member of the sirtuin family of …
The redox stress hypothesis of aging
RS Sohal, WC Orr - Free Radical Biology and Medicine, 2012 - Elsevier
The main objective of this review is to examine the role of endogenous reactive
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …
[HTML][HTML] The plasticity of aging: insights from long-lived mutants
C Kenyon - Cell, 2005 - cell.com
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and
telomeres can all increase the life spans of model organisms. These mutations have …
telomeres can all increase the life spans of model organisms. These mutations have …
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of
regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron …
regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron …
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Rather than being a passive, haphazard process of wear and tear, lifespan can be
modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in …
modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in …
The quest for genetic determinants of human longevity: challenges and insights
Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …
Survival costs of reproduction in Drosophila
Reproduction shortens lifespan in practically all organisms examined so far, but the
underlying mechanisms remain largely unknown to date. Here I review what evolutionary …
underlying mechanisms remain largely unknown to date. Here I review what evolutionary …