Motivational processes underlie behaviors that enrich the human experience, and
impairments in motivation are commonly observed in psychiatric illness. While motivated …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …

Importance Dysfunctional reward processing is a leading candidate mechanism for the
development of certain depressive symptoms, such as anhedonia. However, to our …

Background: Previous research showed that computerized cognitive behavioral therapy can
effectively reduce depressive symptoms. Some mental health apps incorporate gamification …

Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings
suggest that anhedonia is characterized by reduced reward anticipation and motivation of …

This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …

Background Anhedonia, as a dysregulation of the reward circuit, is present in both Major
Depressive Disorder (MDD) and schizophrenia (SZ). Aims To elucidate the clinical and …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Anhedonia is associated with reward-processing deficits of the dopamine system, which
may increase the risk of depression. Nevertheless, few previous studies have examined the …