Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
[HTML][HTML] Variability in cardiac electrophysiology: using experimentally-calibrated populations of models to move beyond the single virtual physiological human …
A Muszkiewicz, OJ Britton, P Gemmell, E Passini… - Progress in biophysics …, 2016 - Elsevier
Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …
individuals of the same species, and has crucial implications in disease progression and …
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
J Tomek, A Bueno-Orovio, E Passini, X Zhou… - elife, 2019 - elifesciences.org
Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …
due to their ability to augment experimental and clinical investigations. Cardiac …
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology
A Carusi, K Burrage… - American Journal of …, 2012 - journals.physiology.org
Computational models in physiology often integrate functional and structural information
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …
Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation
C Sánchez, A Bueno-Orovio, E Wettwer, S Loose… - PloS one, 2014 - journals.plos.org
Aims Human atrial electrophysiology exhibits high inter-subject variability in both sinus
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials
N Zemzemi, MO Bernabeu, J Saiz… - British journal of …, 2013 - Wiley Online Library
Background and Purpose Understanding drug effects on the heart is key to safety
pharmacology assessment and anti‐arrhythmic therapy development. Here our goal is to …
pharmacology assessment and anti‐arrhythmic therapy development. Here our goal is to …
Simulation of the effects of extracellular calcium changes leads to a novel computational model of human ventricular action potential with a revised calcium handling
C Bartolucci, E Passini, J Hyttinen, M Paci… - Frontiers in …, 2020 - frontiersin.org
The importance of electrolyte concentrations for cardiac function is well established.
Electrolyte variations can lead to arrhythmias onset, due to their important role in the action …
Electrolyte variations can lead to arrhythmias onset, due to their important role in the action …
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach
A Bueno-Orovio, C Sánchez, E Pueyo… - Pflügers Archiv-European …, 2014 - Springer
The sodium-potassium pump is widely recognized as the principal mechanism for active ion
transport across the cellular membrane of cardiac tissue, being responsible for the creation …
transport across the cellular membrane of cardiac tissue, being responsible for the creation …
Human induced pluripotent stem cell‐derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block
M Paci, J Hyttinen, B Rodriguez… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Two new technologies are likely to revolutionize cardiac safety
and drug development: in vitro experiments on human‐induced pluripotent stem cell …
and drug development: in vitro experiments on human‐induced pluripotent stem cell …
[HTML][HTML] Recent developments in using mechanistic cardiac modelling for drug safety evaluation
Highlights•Modelling and simulation can streamline decision making in drug safety
testing.•Computational cardiac electrophysiology is a mature technology with a long …
testing.•Computational cardiac electrophysiology is a mature technology with a long …