Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Hemorrhage is the leading cause of preventable death in combat trauma and the secondary
cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur …

Interventions for many medical emergencies including cardiac arrests, strokes, drug
overdoses, seizures, and trauma, are critically time-dependent, with faster intervention …

Hemorrhagic shock (HS) management is based on a timely, rapid, definitive source control
of bleeding/s and on blood loss replacement. Stop** the hemorrhage from progressing …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

Background Blood products are a lifesaving commodity in the treatment of major trauma.
Although there is little evidence for use of pre-hospital blood products (PHBP) in seriously …

The primary aim of this systematic review is to describe the effects of prehospital transfusion
of red blood cells (PHTRBC) on patient outcomes. Damage control resuscitation attempts to …

This narrative review explores the pathophysiology, geographic variation, and historical
developments underlying the selection of fixed ratio versus whole blood resuscitation for …

Background Controversy surrounds the administration of blood products to severely
traumatized patients before they arrive in the hospital in order to compensate for early blood …

METHODS This was a prospective analysis of ARC bundle administration between 2021
and 2023 in an urban EMS system with 70,000 annual responses. The ARC bundle …