Decoding leader cells in collective cancer invasion
Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …
Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
Recent mechanistic and epidemiological studies have provided insights into health benefits
of dietary lycopene to decrease the risk and complications associated with several chronic …
of dietary lycopene to decrease the risk and complications associated with several chronic …
Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
Cell swelling, softening and invasion in a three-dimensional breast cancer model
Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …
critically on the spatial and temporal coordination of cellular physical properties, yet the …
Connexins in cancer: bridging the gap to the clinic
T Aasen, E Leithe, SV Graham, P Kameritsch… - Oncogene, 2019 - nature.com
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …
provide for the direct communication between adjacent cells. This type of intercellular …
Therapeutic strategies targeting connexins
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
MZ Totland, NL Rasmussen, LM Knudsen… - Cellular and Molecular …, 2020 - Springer
Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …
communicate both electrically and metabolically. Gap junctions have a wide diversity of …
Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities
Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …
junctions and polarity while acquiring mesenchymal properties and invasive ability …
Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Connexins are the primary components of gap junctions, providing direct links between cells
under many physiological processes. Here, we demonstrate that in addition to this canonical …
under many physiological processes. Here, we demonstrate that in addition to this canonical …
Communication in the cancer microenvironment as a target for therapeutic interventions
A Dominiak, B Chełstowska, W Olejarz, G Nowicka - Cancers, 2020 - mdpi.com
The tumor microenvironment (TME) is a complex system composed of multiple cells, such as
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …