The physiology of alternative splicing

LE Marasco, AR Kornblihtt - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

PRMT5 function and targeting in cancer

H Kim, AR Ze'ev - Cell stress, 2020 - pmc.ncbi.nlm.nih.gov
Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Integrating circadian dynamics with physiological processes in plants

K Greenham, CR McClung - Nature Reviews Genetics, 2015 - nature.com
The plant circadian clock coordinates the responses to multiple and often simultaneous
environmental challenges that the sessile plant cannot avoid. These responses must be …

Alternative splicing: a pivotal step between eukaryotic transcription and translation

AR Kornblihtt, IE Schor, M Alló, G Dujardin… - … reviews Molecular cell …, 2013 - nature.com
Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

Alternative splicing at the intersection of biological timing, development, and stress responses

D Staiger, JWS Brown - The Plant Cell, 2013 - academic.oup.com
High-throughput sequencing for transcript profiling in plants has revealed that alternative
splicing (AS) affects a much higher proportion of the transcriptome than was previously …

Molecular mechanisms at the core of the plant circadian oscillator

MA Nohales, SA Kay - Nature structural & molecular biology, 2016 - nature.com
Circadian clocks are endogenous timekee** networks that allow organisms to align their
physiology with their changing environment and to perform biological processes at the most …

A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

R Zhang, CPG Calixto, Y Marquez… - Nucleic acids …, 2017 - academic.oup.com
Alternative splicing generates multiple transcript and protein isoforms from the same gene
and thus is important in gene expression regulation. To date, RNA-sequencing (RNA-seq) is …

[HTML][HTML] Alternative splicing in plants–coming of age

NH Syed, M Kalyna, Y Marquez, A Barta… - Trends in plant …, 2012 - cell.com
More than 60% of intron-containing genes undergo alternative splicing (AS) in plants. This
number will increase when AS in different tissues, developmental stages, and environmental …

Wheels within wheels: the plant circadian system

PY Hsu, SL Harmer - Trends in plant science, 2014 - cell.com
Circadian clocks integrate environmental signals with internal cues to coordinate diverse
physiological outputs so that they occur at the most appropriate season or time of day …

Direct repression of evening genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis circadian clock

M Kamioka, S Takao, T Suzuki, K Taki… - The Plant …, 2016 - academic.oup.com
The circadian clock is a biological timekee** system that provides organisms with the
ability to adapt to day-night cycles. Timing of the expression of four members of the …