Review of machine learning methods for RNA secondary structure prediction

Q Zhao, Z Zhao, X Fan, Z Yuan, Q Mao… - PLoS computational …, 2021 - journals.plos.org
Secondary structure plays an important role in determining the function of noncoding RNAs.
Hence, identifying RNA secondary structures is of great value to research. Computational …

[HTML][HTML] Predicting RNA secondary structures from sequence and probing data

R Lorenz, MT Wolfinger, A Tanzer, IL Hofacker - Methods, 2016 - Elsevier
RNA secondary structures have proven essential for understanding the regulatory functions
performed by RNA such as microRNAs, bacterial small RNAs, or riboswitches. This success …

The vienna RNA websuite

AR Gruber, R Lorenz, SH Bernhart… - Nucleic acids …, 2008 - academic.oup.com
Abstract The Vienna RNA Websuite is a comprehensive collection of tools for folding, design
and analysis of RNA sequences. It provides a web interface to the most commonly used …

CONTRAfold: RNA secondary structure prediction without physics-based models

CB Do, DA Woods, S Batzoglou - Bioinformatics, 2006 - academic.oup.com
Motivation: For several decades, free energy minimization methods have been the dominant
strategy for single sequence RNA secondary structure prediction. More recently, stochastic …

The ViennaRNA web services

AR Gruber, SH Bernhart, R Lorenz - RNA bioinformatics, 2015 - Springer
The ViennaRNA package is a widely used collection of programs for thermodynamic RNA
secondary structure prediction. Over the years, many additional tools have been developed …

A coarse graining method for the identification of transition rates between molecular conformations

S Kube, M Weber - The Journal of chemical physics, 2007 - pubs.aip.org
The coarse graining method to be advocated in this paper consists of two main steps. First,
the propagation of an ensemble of molecular states is described as a Markov chain by a …

Complex RNA folding kinetics revealed by single-molecule FRET and hidden Markov models

BG Keller, A Kobitski, A Jäschke… - Journal of the …, 2014 - ACS Publications
We have developed a hidden Markov model and optimization procedure for photon-based
single-molecule FRET data, which takes into account the trace-dependent background …

In silico approaches to RNA aptamer design

M Hamada - Biochimie, 2018 - Elsevier
RNA aptamers are ribonucleic acids that bind to specific target molecules. An RNA aptamer
for a disease-related protein has great potential for development into a new drug. However …

NMR structural profiling of transcriptional intermediates reveals riboswitch regulation by metastable RNA conformations

C Helmling, A Wacker, MT Wolfinger… - Journal of the …, 2017 - ACS Publications
Gene repression induced by the formation of transcriptional terminators represents a prime
example for the coupling of RNA synthesis, folding, and regulation. In this context, map** …

Folding kinetics of large RNAs

M Geis, C Flamm, MT Wolfinger, A Tanzer… - Journal of molecular …, 2008 - Elsevier
We introduce here a heuristic approach to kinetic RNA folding that constructs secondary
structures by stepwise combination of building blocks. These blocks correspond to …