Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as
the root cause of therapy resistance. Recent studies have started to explore the scope of ITH …

Glioblastoma (GBM) is the most prevalent primary brain tumor and ranks among the most
lethal of human cancers with conventional therapy offering only palliation. Great strides have …

Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …

Background: Medulloblastomas (MDB) are malignant, aggressive brain tumors that primarily
affect children. The survival rate for children under 14 is approximately 72%, while for ages …

The Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as
well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various …

Brain tumors represent some of the most malignant cancers in both children and adults.
Current treatment options target the majority of tumor cells but do not adequately target self …

Individuals with mutations in forkhead box G1 (FOXG1) belong to a distinct clinical entity,
termed “FOXG1-related encephalopathy”. There are two clinical phenotypes/syndromes …

Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular
subgroups. The provisional non-wingless-activated (WNT)/non-sonic hedgehog-activated …

Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4)
with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the …

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Despite great
improvements in the therapeutic regimen, relapse and leptomeningeal dissemination still …