Prefrontal cortex and depression

DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022‏ - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

[HTML][HTML] The social cost of depression: Investigating the impact of impaired social emotion regulation, social cognition, and interpersonal behavior on social functioning

A Kupferberg, G Hasler - Journal of Affective Disorders Reports, 2023‏ - Elsevier
Depressive disorders are often accompanied by severe and pervasive impairments in social
functioning, surpassing those experienced by individuals with other chronic medical …

Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024‏ - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …

Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA-and glutamatergic alterations

YT Hu, ZL Tan, D Hirjak, G Northoff - Molecular Psychiatry, 2023‏ - nature.com
The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …

Default mode network activity and connectivity in psychopathology

S Whitfield-Gabrieli, JM Ford - Annual review of clinical …, 2012‏ - annualreviews.org
Neuropsychiatric disorders are associated with abnormal function of the default mode
network (DMN), a distributed network of brain regions more active during rest than during …

Major depressive disorder

C Otte, SM Gold, BW Penninx, CM Pariante… - Nature reviews Disease …, 2016‏ - nature.com
Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

[HTML][HTML] Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium

N Javaheripour, M Li, T Chand, A Krug… - Translational …, 2021‏ - nature.com
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …

Neural circuits underlying the pathophysiology of mood disorders

JL Price, WC Drevets - Trends in cognitive sciences, 2012‏ - cell.com
Although mood disorders constitute leading causes of disability, until recently little was
known about their pathogenesis. The delineation of anatomical networks that support …

Is there a core neural network in empathy? An fMRI based quantitative meta-analysis

Y Fan, NW Duncan, M De Greck, G Northoff - … & Biobehavioral Reviews, 2011‏ - Elsevier
Whilst recent neuroimaging studies have identified a series of different brain regions as
being involved in empathy, it remains unclear concerning the activation consistence of these …

Mind wandering and attention during focused meditation: a fine-grained temporal analysis of fluctuating cognitive states

W Hasenkamp, CD Wilson-Mendenhall, E Duncan… - Neuroimage, 2012‏ - Elsevier
Studies have suggested that the default mode network is active during mind wandering,
which is often experienced intermittently during sustained attention tasks. Conversely, an …