Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Amino acids are the building blocks of protein, but also play important cellular signaling
roles. The mechanisms through which altered levels of many amino acids are sensed and …

Amino acids (AAs) and their metabolites play an important role in neurological health and
function. They are not only the building blocks of protein but are also neurotransmitters. In …

Background Intrinsic capacity is the combination of individual physical and mental abilities,
reflecting the aging degree of the older adults. However, the mechanisms and metabolic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive abilities. AD is associated with aggregation of amyloid-β (Aβ) …

Even apparently healthy aging animals will have some cognitive impairment as identified by
standardized cognitive testing; however, the changes are mild and do not result in altered …

Aging‐induced cognitive impairment is associated with a loss of metabolic homeostasis and
plasticity. An emerging idea is that targeting key metabolites is sufficient to impact the …

Synaptic dysfunction is a hallmark of aging and is found in several neurological disorders
such as Alzheimer's disease. A common mechanism related to synaptic dysfunction is …

Background Tocotrienol is a vitamin E analogue that is known to exert anti-inflammatory and
antioxidant effects. Hence, in the current study, the effects of TRF on the expression of pro …

Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We
previously demonstrated that supplementation with TRF improved cognitive function and …