Engineered platforms for maturing pluripotent stem cell–derived liver cells for disease modeling

Y Yuan, K Cotton, D Samarasekera… - Cellular and Molecular …, 2023 - Elsevier
Several liver diseases (eg, hepatitis B/C viruses, alcoholic/nonalcoholic fatty liver, malaria,
monogenic diseases, and drug-induced liver injury) significantly impact global mortality and …

hESCs-derived organoids achieve liver zonation by LSEC modulation

Y Zhang, C Huang, L Sun, L Zhou, K Liang, Y Niu… - bioRxiv, 2024 - biorxiv.org
Liver zonation, essential for diverse physiological functions, is lacking in existing organoid
models, hindering their ability to recapitulate liver development and pathogenesis …